Sepilift DPHP
INCI: Dipalmitoyl Hydroxyproline
Ingredient Summary
Sepilift DPHP is a plant-derived, anti-aging active ingredient primarily used in skincare formulations to improve skin firmness, reduce wrinkles, and provide deep hydration. It is a lipo-amino acid, meaning it combines fatty acids (palmitic acid) with hydroxyproline, an essential component of collagen.
Ingredient Benefits
Anti-Aging & Wrinkle Reduction:
Stimulates collagen synthesis, helping to reduce the appearance of fine lines and wrinkles.
Prevents collagen degradation by inhibiting matrix metalloproteinases (MMPs), which break down collagen over time.
Skin Firming & Elasticity:
Strengthens the dermal matrix, improving skin elasticity and firmness.
Enhances the skin's natural structure by integrating hydroxyproline, a key amino acid for collagen formation.
Deep Hydration & Moisture Retention:
Improves the skin’s ability to retain moisture, reducing dryness and roughness.
Helps restore the skin’s hydrolipidic barrier, preventing transepidermal water loss (TEWL).
Antioxidant & Protective Effects:
Protects skin cells from oxidative stress and environmental damage.
Acts as a free radical scavenger, reducing premature aging caused by UV radiation and pollution.
Smoothing & Softening:
Improves skin texture by reducing roughness and improving suppleness.
Works synergistically with other emollients to provide a velvety, soft-touch feel.
Ingredient Properties
Oil-Soluble: Works best in oil-based formulations or emulsions.
Collagen Boosting: Mimics hydroxyproline, helping to maintain collagen integrity.
Firming & Lifting Effect: Provides visible tightening over time.
Moisturizing & Barrier Repair: Enhances the skin’s lipid barrier for long-lasting hydration.
Anti-Glycation: Prevents the stiffening of collagen fibers, keeping skin flexible.
Best Suited For:
Anti-aging creams & serums
Firming & lifting treatments
Moisturizers & night creams
Eye creams for wrinkle reduction
Lip care products (plumping & anti-aging)
After-sun care formulations
Body firming creams
How to Use in Formulations:
Recommended Usage Level: 1%
Best Phase for Addition: Add in the oil phase (melt at 80° - 85°C (176°F - 185°F)) before emulsification.
Stability: Compatible with most emulsion systems and works well with other anti-aging ingredients like Vitamin C, peptides, and hyaluronic acid.
Synergistic Ingredients for Enhanced Performance:
Hyaluronic Acid – Enhances hydration and plumps the skin.
Peptides (e.g., Matrixyl 3000) – Works alongside Sepilift DPHP to boost collagen synthesis.
Vitamin C (Ascorbic Acid or Stable Derivatives) – Improves collagen production and brightens skin.
Niacinamide – Strengthens the skin barrier and boosts elasticity.
Coenzyme Q10 (Ubiquinone) – Enhances antioxidant protection.
Final Thoughts:
Sepilift DPHP is a highly effective ingredient for anti-aging skincare, offering both immediate and long-term benefits. It enhances skin firmness, reduces wrinkles, hydrates deeply, and protects against oxidative damage. Its oil-soluble nature makes it ideal for emulsions and rich, nourishing formulas.
Formulations made with this Ingredient:
Usage Rate
1-2%
Solubility
Oil Soluble
Function
Active Ingredient
Formulation Phase
Oil Phase
Formulation
Anti-Aging Serums Eye Creams Moisturizers & Lotions Firming Face Masks Anti-Wrinkle Treatments
pH Range
2-8
How is Made
Sepilift DPHP a plant-derived, is a lipo-amino acid, meaning it is a fatty acid derivative of hydroxyproline. s biodegradable and considered an eco-friendly cosmetic ingredient.